c-KIT D816V Mutation Detection Kit
£519.00
The geneMAP™ c-KIT D816V Mutation Detection Kit leverages allele-specific PCR and multiplex real-time PCR technology for the qualitative detection of the KIT c.2447A>T (D816V) mutation, predominantly found in adults with systemic mastocytosis. This CE-IVD certified kit, compatible with FAM and VIC/HEX two-color real-time PCR instruments, offers superior analytical sensitivity and specificity. Identifying the D816V mutation is crucial for diagnosing systemic mastocytosis and determining treatment strategies, particularly given its association with resistance to imatinib mesylate. The mutation is also observed in certain cases of acute myelogenous leukemia (AML) and seminoma.
geneMAP™ c-KIT D816V Mutation Detection Kit can distinguish normal from (1%) mutated alleles.
- Allele Specific PCR: Ensures high specificity and sensitivity for detecting the KIT D816V mutation.
- Multiplex Real-time PCR Technology: Facilitates rapid and efficient analysis of the mutation.
- Instrument Compatibility: Designed for use with FAM and VIC/HEX two-color real-time PCR instruments, broadening its utility in diverse diagnostic settings.
- CE-IVD Certification: Meets European standards for in vitro diagnostic medical devices, affirming the kit’s reliability and quality.
- Diagnosis of Systemic Mastocytosis: Essential for identifying individuals with the KIT D816V mutation, indicative of systemic mastocytosis.
- Therapeutic Strategy for AML and Seminoma: Useful in detecting the mutation in cases of acute myelogenous leukemia and seminoma, influencing treatment choices.
- Mutation Coverage: Specifically targets the KIT c.2447A>T (D816V) mutation.
- Technology: Utilizes allele-specific and multiplex real-time PCR for efficient and accurate mutation detection.
- Compatibility: Compatible with FAM and VIC/HEX two-color real-time PCR instruments.
- Certification: Carries the CE-IVD mark, indicating compliance with EU regulations for in vitro diagnostic use.
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