CALR Mutation Screening Kit
£1,333.00
The geneMAP™ CALR Mutation Screening Kit is a highly sensitive and specific tool designed for the detection of mutations in the calreticulin (CALR) gene, using allele-specific PCR and multiplex real-time PCR technology. This kit, which is compatible with FAM and VIC/HEX two-color real-time PCR instruments, is intended for research use only (RUO). It’s particularly useful in identifying CALR mutations prevalent in JAK2-negative essential thrombocythemia (ET) and primary myelofibrosis (PMF), aiding in the differential diagnosis of myeloproliferative neoplasms (MPNs).
The geneMAP™ CALR Mutation Screening Kit is a highly sensitive and specific tool designed for the detection of mutations in the calreticulin (CALR) gene, using allele-specific PCR and multiplex real-time PCR technology. This kit, which is compatible with FAM and VIC/HEX two-color real-time PCR instruments, is intended for research use only (RUO). It's particularly useful in identifying CALR mutations prevalent in JAK2-negative essential thrombocythemia (ET) and primary myelofibrosis (PMF), aiding in the differential diagnosis of myeloproliferative neoplasms (MPNs).
- Allele Specific PCR: Ensures high specificity and sensitivity for CALR mutation detection.
- Multiplex Real-time PCR Technology: Facilitates the fast and efficient analysis of CALR gene mutations.
- Compatibility: Designed for use with FAM, VIC/HEX two-color real-time PCR instruments, offering flexibility in laboratory settings.
- Research Use Only: Not for use in diagnostic procedures, focusing on research to understand the genetic basis of MPNs better.
- Accurate Mutation Identification: Provides reliable detection of the most common CALR mutations, including the 52 bp deletion (type-1) and the 5 bp insertion (type-2), along with other less common variants.
- Rapid and User-Friendly: Simplifies the genetic testing process, enabling quick and efficient screening of CALR mutations.
- Comprehensive Mutation Screening: Offers a thorough approach to understanding the genetic landscape of MPNs, particularly in JAK2-negative cases.
Research in Myeloproliferative Neoplasms: Critical for studying the role of CALR mutations in the pathogenesis and prognosis of ET and PMF, and for distinguishing these conditions from benign reactive processes and other hematologic malignancies.
- Mutation Coverage: Targets a variety of insertion or deletion mutations in exon 9 of the CALR gene, including type-1 (52 bp deletion) and type-2 (5 bp insertion) mutations, among others.
- Technology: Utilizes allele-specific and multiplex real-time PCR for efficient and accurate mutation detection.
- Compatibility: Suitable for use with FAM and VIC/HEX two-color real-time PCR instruments.
- Usage: Designated for research purposes only, not approved for diagnostic use.
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