MPL W515A/L/K/R Mutation Detection Kit
£889.00
The geneMAP™ MPL W515A/L/K/R Mutation Detection Kit is engineered for the high-precision detection of clinically significant mutations within the MPL gene, specifically W515A, W515L, W515K, and W515R. Utilizing allele-specific PCR and multiplex real-time PCR technology, this kit offers superior analytical sensitivity and specificity. It’s designed for compatibility with FAM and VIC/HEX two-color real-time PCR instruments and is CE-IVD certified. This kit serves as a critical tool for diagnosing and understanding the genetic basis of myeloproliferative neoplasms (MPNs), including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), especially among patients who are JAK2 V617F-negative.
- Allele Specific PCR: Ensures high specificity and sensitivity in detecting MPL mutations.
- Multiplex Real-time PCR Technology: Facilitates the simultaneous detection of 7 clinically relevant MPL mutations, enhancing diagnostic efficiency.
- Compatibility: Works seamlessly with FAM, VIC/HEX two-color real-time PCR instruments, offering broad usability.
- CE-IVD Certification: Meets European standards for in vitro diagnostic medical devices, ensuring reliability and quality in diagnostics.
- Diagnosis and Prognosis of MPNs: Essential for identifying MPL mutations in patients with polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), particularly those who are negative for the JAK2 V617F mutation.
- Genetic Screening: Supports genetic screening efforts in populations at risk or suspected of having MPNs, aiding in early detection and intervention.
- Mutation Coverage: Detects MPL W515A, W515L, W515K, and W515R mutations among others, addressing the most clinically relevant variations.
- Technology: Utilizes allele-specific and multiplex real-time PCR for efficient and accurate mutation detection.
- Compatibility: Suitable for use with FAM and VIC/HEX two-color real-time PCR instruments.
- Certification: Carries the CE-IVD marking, indicating its approved use within the European Union for in vitro diagnostics.
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