The geneMAP™ MGMT Methylation Analysis Kit is a cutting-edge tool designed for the detection and quantitative analysis of O(6)-methylguanine-DNA methyltransferase (MGMT) promoter hypermethylation in genomic DNA from glioblastoma multiforme (GBM) tumors. Utilizing methylation-specific real-time PCR (MSP) technology, this CE-IVD certified kit offers superior analytical sensitivity and specificity and is compatible with FAM and VIC/HEX two-color real-time PCR instruments. MGMT promoter methylation is a key biomarker for increased sensitivity to alkylating agents like temozolomide, making it crucial for therapeutic decision-making and prognosis in GBM treatment.
The geneMAP™ MGMT Methylation Analysis Kit is a cutting-edge tool designed for the detection and quantitative analysis of O(6)-methylguanine-DNA methyltransferase (MGMT) promoter hypermethylation in genomic DNA from glioblastoma multiforme (GBM) tumors. Utilizing methylation-specific real-time PCR (MSP) technology, this CE-IVD certified kit offers superior analytical sensitivity and specificity and is compatible with FAM and VIC/HEX two-color real-time PCR instruments. MGMT promoter methylation is a key biomarker for increased sensitivity to alkylating agents like temozolomide, making it crucial for therapeutic decision-making and prognosis in GBM treatment.
- Methylation-Specific PCR: Enhances sensitivity and specificity in detecting MGMT promoter methylation.
- Multiplex Real-time PCR Technology: Enables fast, efficient, and quantitative analysis of methylation levels.
- Instrument Compatibility: Designed for use with FAM and VIC/HEX two-color real-time PCR instruments, broadening its applicability.
- CE-IVD Certification: Meets European standards for in vitro diagnostic medical devices, affirming its reliability and quality.
- Prognostic and Therapeutic Decision-Making in GBM: Essential for assessing MGMT promoter methylation status, which is linked to better responses to alkylating agents and favorable prognosis in glioblastoma multiforme patients.
- Technology: Utilizes methylation-specific and multiplex real-time PCR for precise detection and quantification of MGMT promoter hypermethylation.
- Compatibility: Suitable for FAM and VIC/HEX two-color real-time PCR instruments.
- Methylation Analysis: Offers quantitative methylation analysis, calculating the methylation level percentage.
- Certification: Carries the CE-IVD mark, indicating compliance with EU regulations for in vitro diagnostic use.
- Methylation-Specific PCR: Enhances sensitivity and specificity in detecting MGMT promoter methylation.
- Multiplex Real-time PCR Technology: Enables fast, efficient, and quantitative analysis of methylation levels.
- Instrument Compatibility: Designed for use with FAM and VIC/HEX two-color real-time PCR instruments, broadening its applicability.
- CE-IVD Certification: Meets European standards for in vitro diagnostic medical devices, affirming its reliability and quality.
- Prognostic and Therapeutic Decision-Making in GBM: Essential for assessing MGMT promoter methylation status, which is linked to better responses to alkylating agents and favorable prognosis in glioblastoma multiforme patients.
- Technology: Utilizes methylation-specific and multiplex real-time PCR for precise detection and quantification of MGMT promoter hypermethylation.
- Compatibility: Suitable for FAM and VIC/HEX two-color real-time PCR instruments.
- Methylation Analysis: Offers quantitative methylation analysis, calculating the methylation level percentage.
- Certification: Carries the CE-IVD mark, indicating compliance with EU regulations for in vitro diagnostic use.
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