FIP1L1-PDGFRA Detection Kit
£735.00
The geneMAP™ FIP1L1-PDGFRA Detection Kit is intended for detection and quantitation of FIP1L1 exon 9/PDGFRA exon 12, FIP1L1 exon 10/PDGFRA exon 12, FIP1L1 exon11/PDGFRA exon 12, FIPL1 exon 12/PDGFRA exon 12 & FIPL1 exon 13/PDGFRA exon 12 fusion transcripts in bone marrow or peripheral blood samples of patients who have been diagnosed with idiopathic hypereosinophilic syndrome and eosinophilia-associated myeloproliferative disorders. The results obtained are intended to be used as an aid to monitor efficacy of treatment in patients undergoing therapy, and for minimal residual disease (MRD) follow-up to monitor disease relapse.
- Superior Analytical Sensitivity: Achieves a log4 reduction in detection sensitivity, enabling the identification of low levels of the FIP1L1-PDGFRA fusion transcript.
- One-Step RT-qPCR Technology: Streamlines the testing process, making it both quick and straightforward to execute.
- Multiplex PCR: Facilitates accurate relative quantitation by comparing fusion transcripts against ABL1 gene expression, enhancing diagnostic precision.
- Instrument Compatibility: Designed for use with FAM and VIC/HEX dual-color real-time PCR instruments, ensuring versatility across laboratory settings.
- CE-IVD Certification: Meets European standards for in vitro diagnostic medical devices, ensuring the kit’s reliability and quality.
- Leukemia Diagnosis and Monitoring: Specifically targets the FIP1L1-PDGFRA fusion gene for patients suspected of or diagnosed with chronic eosinophilic leukemia or a subset of acute myeloid leukemia (AML), playing a key role in diagnosis, prognosis, and treatment monitoring strategies.
- Technology: Utilizes one-step RT-qPCR with multiplex PCR for the detection and relative quantitation of the FIP1L1-PDGFRA fusion transcript.
- Sensitivity: Features superior analytical sensitivity (log4 reduction) for detecting low levels of the target gene.
- Compatibility: Compatible with FAM and VIC/HEX dual-color real-time PCR instruments.
- Certification: Carries the CE-IVD mark, indicating compliance with EU regulations for in vitro diagnostic use.
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